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  • Writer's pictureDr. Jason Bachewich ND

Mistletoe in the treatment of Lyme disease.

Updated: Feb 7

Unlocking the Potential: Mistletoe Injection and Lyme Disease

When you think of mistletoe, you may conjure up images of holiday traditions like kissing under the mistletoe. However, mistletoe has a lesser-known side beyond the realm of romance. In recent years, mistletoe injection therapy has been explored as a complementary approach to address Lyme Disease, a complex and often challenging-to-treat illness. In this blog post, we'll delve into the intriguing connection between mistletoe therapy and Lyme Disease and explore its potential benefits in the fight against this elusive condition.

Understanding Lyme Disease

Lyme Disease is a tick-borne illness caused by the spirochete bacterium Borrelia burgdorferi. It is characterized by a wide range of symptoms, including fever, fatigue, joint pain, and skin rashes, often resembling a bull's-eye. If left untreated or undiagnosed, Lyme Disease can progress to affect various body systems, leading to more severe symptoms, such as neurological and cardiac issues.

One of the challenges of Lyme Disease is its ability to mimic other conditions and evade detection, leading to misdiagnoses and delayed treatment. As a result, patients seek complementary and alternative therapies like mistletoe.

Mistletoe Therapy: An Overview

Mistletoe, particularly European mistletoe (Viscum album), has been used for centuries in traditional medicine for its potential therapeutic properties. While it is more commonly associated with cancer treatment in some parts of the world, researchers have started to investigate its potential benefits for other health conditions, including Lyme Disease.

The Potential Benefits of Mistletoe Injection for Lyme Disease

  1. Immunomodulation: Mistletoe extracts contain compounds that are believed to modulate the immune system. In the context of Lyme Disease, this immunomodulatory effect may help regulate the immune response, potentially reducing inflammation and autoimmune reactions triggered by the infection.

  2. Antimicrobial Properties: Some studies suggest that mistletoe extracts may have antimicrobial properties, which could be beneficial in addressing Lyme Disease. While it may not directly target Borrelia bacteria, it may help create a less favorable environment for their survival.

  3. Symptom Management: Lyme Disease is often accompanied by a range of symptoms, including fatigue, joint pain, and cognitive dysfunction. Mistletoe injection therapy may help alleviate some of these symptoms, contributing to an improved quality of life for individuals with Lyme Disease.

  4. Enhanced Immune Response: Lyme Disease can suppress the immune system, allowing the bacteria to thrive. Mistletoe therapy may enhance immune function, helping the body mount a more effective defense against the infection.

Considerations and Future Research

While mistletoe injection therapy shows promise as a complementary approach to Lyme Disease treatment, several important considerations should be kept in mind:

  • Consult a Lyme-Literate Healthcare Provider: If you suspect you have Lyme Disease or are considering mistletoe injection therapy, it is crucial to consult with a healthcare provider who specializes in Lyme Disease. They can provide a comprehensive evaluation and guidance on the most appropriate treatment options.

  • Comprehensive Treatment: Mistletoe injection therapy should not be viewed as a standalone treatment for Lyme Disease. It is most effective when integrated into a comprehensive treatment plan that may include antibiotics, herbal remedies, and lifestyle modifications.

  • Individualized Approach: Lyme Disease presents differently in each individual. What works for one person may not be suitable for another. An individualized treatment approach, tailored to your specific symptoms and needs, is essential.

  • Research Continues: While there is emerging research on mistletoe therapy for Lyme Disease, more studies are needed to fully understand its efficacy, safety, and optimal dosing protocols.


Mistletoe therapy is an intriguing complementary approach to Lyme Disease treatment, offering potential benefits in terms of immunomodulation, symptom management, and immune support. However, it should be viewed as part of a broader treatment strategy under the guidance of a healthcare provider experienced in Lyme Disease management.

As research in this area continues to evolve, mistletoe therapy may become an increasingly valuable tool in the fight against Lyme Disease, providing hope for improved outcomes and a better quality of life for those living with this challenging condition.


  1. Kienle GS, Kiene H. Influence of Viscum album L (European mistletoe) extracts on quality of life in cancer patients: a systematic review of controlled clinical studies. Integrative Cancer Therapies. 2010;9(2):142-157. Read Here

  2. Büssing A, Schietzel M. Apoptosis-inducing properties of Viscum album L. extracts from different host trees, correlate with their content of toxic mistletoe lectins. Anticancer Res. 1999;19(1A):23-28. Read Here

  3. Büssing A. Mistletoe. The Genus Viscum. Harwood Academic Publishers, Amsterdam. 2000.

  4. Cameron DJ, Johnson LB, Maloney EL. Evidence assessments and guideline recommendations in Lyme disease: the clinical management of known tick bites, erythema migrans rashes and persistent disease. Expert Rev Anti Infect Ther. 2004;2(6 Suppl):S1-13. Read Here

  5. Wormser GP, Nadelman RB, Dattwyler RJ, et al. Practice Guidelines for the Treatment of Lyme Disease. Clinical Infectious Diseases. 2000;31(Supplement_1):S1-S14. Read Here

  6. The International Lyme and Associated Diseases Society (ILADS). Evidence-based guidelines for the management of Lyme disease. Expert Rev Anti Infect Ther. 2004;2(1 Suppl):S1-13. Read Here

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